Broncos 41, Cardinals 20: Peyton Manning joined Brett Favre in the NFL's most exclusive of clubs with his 500th touchdown pass Sunday when Denver handed visiting Arizona its first loss.
Manning finished with four TD throws, moving him within five of Favre's record 508. Manning found tight end Julius Thomas twice in the end zone, including the touchstone touchdown, a 7-yard dart in the first quarter.
Yet, it was wide receiver Demaryius Thomas who had the biggest day for the Broncos (3-1) with eight catches for a team-record 226 yards and two TDs. That beat Shannon Sharpe's mark of 214 yards set against Kansas City in 2002.
Demaryius Thomas caught touchdown passes of 31 and 86 yards -- and his 77-yard TD was nullified by left tackle Ryan Clady's chop block in the third quarter. Arizona (3-1) lost for the first time and saw quarterback Drew Stanton leave with a possible concussion.
Manning finished 31 of 47 for 479 yards, 4 TDs and 2 interceptions. Emmanuel Sanders caught seven passes for 101 yards.
Stanton, subbing for Carson Palmer again, was knocked from the game on a hard hit by Von Miller in the third period and Logan Thomas came in for Arizona (3-1). Stanton finished 11 of 26 for 118 yards.
Browns 29, Titans 28: Cleveland shook off a sluggish start with a finish to remember.
Brian Hoyer threw a 6-yard touchdown pass to Travis Benjamin with 1:09 left, and the visiting Browns rallied from a 25-point deficit for their biggest comeback in franchise history.
The Browns (2-2) had never come back from more than 20 points before, and this easily topped the comeback on Dec. 4, 1966, when Cleveland trailed the Giants 34-14 and won 49-40, according to STATS Inc.
This time, the Browns also won a road game for the first time since Sept. 22, 2013, at Minnesota, and they couldn't have made it tougher on themselves as they fell behind 28-3 in the first half. They snapped a seven-game road skid scoring 26 unanswered points, including 16 in the fourth quarter.
The Titans (1-4) had a massive collapse -- their biggest since moving to Tennessee in 1997. Jake Locker didn't return after hurting his right thumb in the second quarter, and backup Charlie Whitehurst couldn't protect the big lead.
Saints 37, Buccaneers 31: With Drew Brees having a difficult day, running backs Khiry Robinson and Pierre Thomas carried host New Orleans to a comeback victory it sorely needed.
With star tight end Jimmy Graham sidelined, Robinson's tackle-breaking 18-yard touchdown run...